| Bioactivity | I-BOP is an agonist for thromboxane A2 receptor (TP) with a KD of 0.61 nM. I-BOP promotes proliferation through activation of PI3K pathway in vascular smooth muscle[1]. I-BOP dose-dependently biphasicly affects the excitatory postsynaptic potential (e.p.s.p.) in hippocampal neurons[2]. |
| Invitro | I-BOP (1-100 nM) 激活 MAP 激酶，刺激酪氨酸磷酸化，从而激活 PI3K 信号通路[1]。I-BOP (0.1-3 μM) 在低浓度时通过增加神经递质释放，增强海马 CA1 神经元的突触传递；在高浓度时通过降低膜输入阻力，抑制海马 CA1 神经元的兴奋性突触传递[2]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> I-BOP 相关抗体: Western Blot Analysis[1] Cell Line: |
| CAS | 128719-90-4 |
| Formula | C23H29IO5 |
| Molar Mass | 512.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Morinelli TA, et al., Tyrosine phosphorylation of phosphatidylinositol 3-kinase and of the thromboxane A2 (TXA2) receptor by the TXA2 mimetic I-BOP in A7r5 cells. Biochem Pharmacol. 1997 Jun 15;53(12):1823-32. [2]. Hsu KS, et al., Thromboxane A2 agonist modulation of excitatory synaptic transmission in the rat hippocampal slice. Br J Pharmacol. 1996 Aug;118(8):2220-7. |