| Bioactivity | Hypoglycemic agent 3 (Compound H26), a derivative of corosolic acid, exhibits lipid-lowering and significant hypoglycemic effects and can be used as a hypoglycemic agent. Hypoglycemic agent 3 inhibits insulin resistance by targeting MCCC1 and can be used in the study of type 2 diabetes[1]. |
| Invitro | Hypoglycemic agent 3 (Compound H26) (40-320 μM; 24 h) 在 HepG2 细胞中没有表现出明显的细胞毒性[1]。Hypoglycemic agent 3 (20-40 μM) 主要通过增加 HepG2 细胞中的 MCCC1 来抑制胰岛素抵抗[1]。Hypoglycemic agent 3 (20 μM; 1 h) 在 HepG2 细胞中显著抑制 Glucosamine (18 mM; 18 h) (HY-B1125) 诱导的葡萄糖生成增加[1]。Hypoglycemic agent 3 (2.5-20 μM; 1 h) 能激活 PI3K-AKT 并抑制 HepG2 细胞中的 NF-κB 信号通路[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Hypoglycemic agent 3 相关抗体: Western Blot Analysis[1] Cell Line: |
| Formula | C32H51NO5 |
| Molar Mass | 529.75 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Huang G, et al. Corosolic acid and its derivatives targeting MCCC1 against insulin resistance and their hypoglycemic effect on type 2 diabetic mice[J]. European Journal of Medicinal Chemistry, 2024: 117184. |