| Bioactivity | Hydrocortisone hemisuccinate hydrate (5,6,7-Trihydroxyflavone hydrate), a physiological glucocorticoid, is an orally active steroidal anti-in ammatory agent (SAID). Hydrocortisone hemisuccinate hydrate inhibits proinflammatory cytokine activity, with IC50s of 6.7 and 21.4 μM for IL-6 and IL-3, respectively. Hydrocortisone hemisuccinate hydrate can be used for the research of ulcerative colitis (UC). |
| CAS | 83784-20-7 |
| Formula | C25H36O9 |
| Molar Mass | 480.55 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kang BS, et, al. Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity. Biol Pharm Bull. 2001 Jun;24(6):701-3. [2]. You YC, et, al. In vitro and in vivo application of pH-sensitive colon-targeting polysaccharide hydrogel used for ulcerative colitis therapy. Carbohydr Polym. 2015 Oct 5;130:243-53. [3]. Langhoff E, et, al. The immunosuppressive potency in vitro of physiological and synthetic steroids on lymphocyte cultures. Int J Immunopharmacol. 1987;9(4):469-73. |
Hydrocortisone hemisuccinate hydrate
CAS: 83784-20-7 F: C25H36O9 W: 480.55
Hydrocortisone hemisuccinate hydrate (5,6,7-Trihydroxyflavone hydrate), a physiological glucocorticoid, is an orally act
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