| Bioactivity | Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from cytosol to mitochondria, blocks Bax from the inactive to active conformation. Humanin is a mitochondria-associated peptide with a neuroprotective effect against AD-related neurotoxicity. Humanin also improves overall insulin sensitivity in animal. Humanin are related to aging[1][2]. Humanin analogue, in which the serine at position 14 is replaced by glycine, names HNG[2]. |
| Invitro | Humanin (40 nM，罗丹明偶联；30 min) 抑制野生型 HCT116 细胞受 Bax 蛋白诱导的细胞死亡[1]。Humanin (100 μM；10 min) 阻断 Bax 与分离线粒体的关联，并抑制野生型 HCT116 细胞中细胞色素 c 的释放[1]。Humanin 减少 0.2 mM STS 诱导的细胞半凋亡[1]。Humanin 不能抑制 Bax 缺陷的 HCT116 细胞的凋亡[1]。 |
| Name | Humanin |
| CAS | 330936-69-1 |
| Sequence | Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Ser-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala |
| Shortening | MAPRGFSCLLLLTSEIDLPVKRRA |
| Formula | C119H204N34O32S2 |
| Molar Mass | 2687.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
Humanin
CAS: 330936-69-1 F: C119H204N34O32S2 W: 2687.23
Humanin, an anti-apoptotic peptide of 24 amino acids, is a Bax inhibitor. Humanin prevents the translocation of Bax from
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