| Bioactivity | Hsp90-Cdc37-IN-2 (Compound 41) is an inhibitor for the interaction between heat shock protein 90 (Hsp90) and cyclin 37 (Cdc37). Hsp90-Cdc37-IN-2 inhibits the proliferation of cancer cell A549, MCF-7, HOS and HepG2 with IC50 of 0.41-0.94 μM. Hsp90-Cdc37-IN-2 decreases the mitochondrial membrane potential, induces apoptosis and arrest cell cycle at G0/G1 phase in A549[1]. |
| CAS | 2413849-81-5 |
| Formula | C42H48FNO6 |
| Molar Mass | 681.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li N, et al., Discovery of Novel Celastrol Derivatives as Hsp90-Cdc37 Interaction Disruptors with Antitumor Activity. J Med Chem. 2019 Dec 12;62(23):10798-10815. |
Hsp90-Cdc37-IN-2
CAS: 2413849-81-5 F: C42H48FNO6 W: 681.83
Hsp90-Cdc37-IN-2 (Compound 41) is an inhibitor for the interaction between heat shock protein 90 (Hsp90) and cyclin 37 (
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