| Bioactivity | Hemitoxin, a scorpion-venom peptide, is a K+ channel blocker. Hemitoxin blocks rat Kv1.1, Kv1.2 and Kv1.3 channels expressed in Xenopus oocytes with IC50 values of 13 nM, 16 nM and 2 nM, respectively[1]. |
| Name | Hemitoxin |
| Sequence | Ile-Lys-Cys-Thr-Leu-Ser-Lys-Asp-Cys-Tyr-Ser-Pro-Cys-Lys-Lys-Glu-Thr-Gly-Cys-Pro-Arg-Ala-Lys-Cys-Ile-Asn-Arg-Asn-Cys-Lys-Cys-Tyr-Gly-Cys-Ser (Disulfide bridge:Cys3-Cys24;Cys9-Cys29;Cys13-Cys19;Cys31-Cys34) |
| Shortening | IKCTLSKDCYSPCKKETGCPRAKCINRNCKCYGCS (Disulfide bridge:Cys3-Cys24;Cys9-Cys29;Cys13-Cys19;Cys31-Cys34) |
| Formula | C159H259N49O49S8 |
| Molar Mass | 3897.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Najet Srairi-Abid, et al. Hemitoxin, the first potassium channel toxin from the venom of the Iranian scorpion Hemiscorpius lepturus. FEBS J. 2008 Sep;275(18):4641-50. |