Heliquinomycin_product_DataBase

Bioactivity	Heliquinomycin is an inhibitor of DNA helicase (Ki: 6.8 μM) and inhibits DNA and RNA synthesis. Heliquinomycin is effective against Gram-positive bacteria strains. Heliquinomycin inhibits cancer cell growth[1][2].
Invitro	Heliquinomycin (18 h) 对革兰氏阳性菌株表现出很强的抑制活性，MIC 值为 0.1-0.39 μM[1]。Heliquinomycin 抑制 HeLa S3、LI210 白血病、IMC、癌、B16 黑色素瘤细胞的生长，IC50s 为 0-1.6 μg/mL[1]。Heliquinomycin (30 和 100 μg/mL) 抑制拓扑异构酶 II 和 I 酶活性[2]。
In Vivo	Heliquinomycin (100 mg/kg, i.p.) 对小鼠没有任何毒性[1]。
Name	Heliquinomycin
CAS	178182-49-5
Formula	C33H30O17
Molar Mass	698.58
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chino M, et al. Heliquinomycin, a new inhibitor of DNA helicase, produced by Streptomyces sp. MJ929-SF2 I. Taxonomy, production, isolation, physico-chemical properties and biological activities. J Antibiot (Tokyo). 1996 Aug;49(8):752-7. [2]. Chino M,et al. Effect of a novel antibiotic, heliquinomycin, on DNA helicase and cell growth. J Antibiot (Tokyo). 1998 May;51(5):480-6.

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