| Bioactivity | Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a Ki of 21 nM and an EC50 of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain[1]. |
| Target | Ki: 21 nM (KOR)ED50: 45 nM (KOR) |
| Name | Helianorphin-19 |
| CAS | 2883653-86-7 |
| Sequence | Cyclo(Cys-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Cys-Ile-Arg-Pro-Lys-Leu-Lys) (Disulfide bridge: Cys1-Cys9) |
| Shortening | Cyclo(CYGGFLRRCIRPKLK) (Disulfide bridge: Cys1-Cys9) |
| Formula | C81H132N26O16S2 |
| Molar Mass | 1790.21 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Muratspahić E, et al. Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain. J Med Chem. 2021 Jul 8;64(13):9042-9055. |
Helianorphin-19
CAS: 2883653-86-7 F: C81H132N26O16S2 W: 1790.21
Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a Ki of 21 nM and an EC50 of 45 nM. He
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