Helenalin acetate_product_DataBase

Bioactivity	Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities[1].
Invitro	Helenalin acetate（0.1-1 μM；持续 7 天）显着抑制 3T3-L1 细胞的分化[1]。Helenalin acetate对急性髓性白血病细胞具有抗增殖作用，对正常造血祖细胞无作用[1]。Helenalin acetate 通过结合到 C/EBPβ 的 N 末端部分来抑制 C/EBPβ，从而破坏 C/EBPβ 与共激活因子 p300 的合作。Helenalin acetate 仅选择性抑制全长（富含肝脏的激活蛋白* (LAP*)）同种型，但不抑制稍短的 (LAP) 同种型[1]。 Cell Differentiation Assay[1] Cell Line:
Name	Helenalin acetate
CAS	10180-86-6
Formula	C17H20O5
Molar Mass	304.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jakobs A, et al. Helenalin Acetate, a Natural Sesquiterpene Lactone with Anti-inflammatory and Anti-cancer Activity, Disrupts the Cooperation of CCAAT Box/Enhancer-binding Protein β (C/EBPβ) and Co-activator p300. J Biol Chem. 2016 Dec 9;291(50):26098-26108.

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