| Bioactivity | Hedgehog IN-7 (Compound 8g), a purine derivative, acts as an inhibitor of Hedgehog, capable of reducing the expression of Hedgehog genes and inhibiting Hedgehog signaling. Hedgehog IN-7 has significant cytotoxicity and selectivity towards theHedgehog pathway-dependent pancreatic cancer cell Mia-PaCa-2 cells and can be used in the research of pancreatic cancer[1]. |
| Invitro | Hedgehog IN-7 (Compound 8g) 对 MIA-PaCa-2 细胞具有细胞毒性 (IC50 = 4.11 μM)，对 HEK293 无细胞毒性 (IC50 ) > 50 μM)[1]。Hedgehog IN-7 (48 h) 在 NIH3T3 SHh-Light II 细胞中能抑制 Hedgehog 的信号传导，IC50 值为 6.4 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Hedgehog IN-7 相关抗体: |
| Formula | C27H27FN8 |
| Molar Mass | 482.56 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Espinosa-Bustos C, et al. New Smoothened ligands based on the purine scaffold as potential agents for treating pancreatic cancer[J]. Bioorganic Chemistry, 2024, 151: 107681. |