| Bioactivity | Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization[1]. |
| Invitro | Q29 (1-10 μM；24 小时) 剂量依赖性地抑制 Shh-N 激活的 GLI1 蛋白表达[1]。Q29 (1-10 μM；24 + 12 小时) 以剂量依赖性方式抑制 Hh 信号依赖性细胞增殖[1]。在不同浓度的 Shh-N 存在下，Q29 抑制 Gli-荧光素酶活性，IC50 为 1.33 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Hedgehog IN-6 相关抗体: Western Blot Analysis Cell Line: |
| In Vivo | Q29 (90 mg/kg；口服管饲；每天两次；13 天) 可有效抑制 Ptch1+/P53/ 小鼠的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C25H43NO2 |
| Molar Mass | 389.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Liu YB, et al. A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened. Cell Chem Biol. 2024 Feb 28:S2451-9456(24)00076-X. |