| Bioactivity | Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits several HECT ligases in tissue culture cells (IC50s=6.8, 6.3, and 6.9 μM for Smurf2, Nedd4, and WWP1 HECT ligase domains, respectively)[1]. | ||||||||||||
| Name | Heclin | ||||||||||||
| CAS | 890605-54-6 | ||||||||||||
| Formula | C17H17NO3 | ||||||||||||
| Molar Mass | 283.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Mund T, et al. Peptide and small molecule inhibitors of HECT-type ubiquitin ligases. Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16736-41. |
Heclin
CAS: 890605-54-6 F: C17H17NO3 W: 283.32
Heclin is a HECT E3 ubiquitin ligases inhibitor. Heclin inhibits several HECT ligases in tissue culture cells (IC50s=6.8
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