| Bioactivity | HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized proteins, SGK3 and VPS34, with a DC50 of 3-10 nM, remarkably selective inducing only degradation of the Halo tagged endogenous VPS34 complex (VPS34, VPS15, Beclin1, and ATG14). | ||||||||||||
| Name | HaloPROTAC-E | ||||||||||||
| CAS | 2365478-58-4 | ||||||||||||
| Formula | C39H56ClN5O8S | ||||||||||||
| Molar Mass | 790.41 | ||||||||||||
| Appearance | Oil | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Tovell H, Testa A, Maniaci C, et al. Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader. ACS Chem Biol. 2019;14(5):882-892. |
HaloPROTAC-E
CAS: 2365478-58-4 F: C39H56ClN5O8S W: 790.41
HaloPROTAC-E is a novel HaloPROTAC potent degrader, inducing reversible degradation of two endosomally localized protein
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