| Bioactivity | HadAB-IN-1 is a potent HadAB inhibitor. HadAB-IN-1 inhibits HadAB enzyme complexes activity with an IC50 value of 0.03 μM. HadAB-IN-1 also affects mycolic acid biosynthesis in Mycobacterium tuberculosis (Mtb). HadAB-IN-1 can be used for the research of tuberculosis (TB)[1]. |
| Target | IC50: 0.03 μM (HadAB enzyme complexes); MIC50: 4.7 μM (Mtb). |
| Invitro | HadAB-IN-1has inhibition activity for HadAB enzyme complexes with an IC50value of 0.03 μM[1].HadAB-IN-1 can inhibit Mycobacterium tuberculosis (Mtb) with an MIC50value of 4.7 μM[1]. |
| Name | HadAB-IN-1 |
| CAS | 1097120-47-2 |
| Formula | C19H17BrClN3O3S |
| Molar Mass | 482.78 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Vinayak Singh, et al. 1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis. ACS Infect Dis. 2022 Nov 11;8(11):2315-2326. |
HadAB-IN-1
CAS: 1097120-47-2 F: C19H17BrClN3O3S W: 482.78
HadAB-IN-1 is a potent HadAB inhibitor. HadAB-IN-1 inhibits HadAB enzyme complexes activity with an IC50 value of 0.03
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