| Bioactivity | HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells[1][2][3]. |
| Invitro | HXR9 (60μM; 4 hours) blocks the interaction between PBX and HOX[1].HXR9 (60μM; 2 hours) triggers apoptosis in B16 and primary melanoma cells[1].HXR9 (60μM; 2 hours) causes specific transcriptional changes[1].HXR9 (B16 cells) shows antiproliferative activity with an IC50 of 20μM[1]. Western Blot Analysis Cell Line: |
| Name | HXR9 |
| CAS | 917953-08-3 |
| Sequence | Trp-Tyr-Pro-Trp-Met-Lys-Lys-His-His-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg |
| Shortening | WYPWMKKHHRRRRRRRRR |
| Formula | C119H193N53O20S |
| Molar Mass | 2718.21 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
HXR9
CAS: 917953-08-3 F: C119H193N53O20S W: 2718.21
HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction b
Data collection：peptidedb@qq.com
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