| Bioactivity | HX600 is a synthetic agonist for RXR (Retinoid X Receptor) heterodimer complex. HX600 prevents ischemia-induced neuronal damage. HX600 has orally bioactivity[1]. | |||||||||
| Invitro | HX600 (100-1000 μM, 24 h) 对谷氨酸暴露无直接神经保护作用[1]。HX600 (1 μM, 24 h) 抑制原代小胶质细胞中炎症介质的表达，防止炎症诱导的神经元死亡[1]。 0 --> HX600 相关抗体: Apoptosis Analysis[1] Cell Line: | |||||||||
| In Vivo | HX600 (60 mg/kg，口服，每 24h) 可减轻永久性缺血模型的缺血损伤和运动缺陷，并可改善缺血脑 Iba-1、phospho-p38 和 TREM-2 的免疫反应[1]。 Animal Model: | |||||||||
| Name | HX600 | |||||||||
| CAS | 172705-89-4 | |||||||||
| Formula | C29H30N2O2 | |||||||||
| Molar Mass | 438.56 | |||||||||
| Appearance | 固体 | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Siddhesh S Kamat, et al. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol 2015 Feb;11(2):164-71. [2]. Hiroki Umemiya, et al. Action Mechanism of Retinoid-Synergistic Dibenzodiazepines. Biochem Biophys Res Commun. 1997 Apr 7;233(1):121-5. |