| Bioactivity | HU 433 is a synthetic cannabinoid CB2 receptor agonist that is an enantiomer of HU 308. HU 433 exerts its anti-inflammatory and neuroprotective effects by binding to the CB2 receptor. CB2 receptor is mainly expressed on immune cells, and its activation can regulate immune response and inflammatory processes. HU 433 can also affect microglial signaling pathways, especially LPS and IFNγ-mediated signaling pathways, including the phosphorylation of MAPKs (mitogen activated protein kinases) such as ERK1/2, JNK, p38 and Akt. HU 433 can be used in the study of neuroinflammation and retinal diseases[1]. |
| CAS | 1220887-84-2 |
| Formula | C27H42O3 |
| Molar Mass | 414.62 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Young A P, et al. Enantiomeric Agonists of the Type 2 Cannabinoid Receptor Reduce Retinal Damage during Proliferative Vitreoretinopathy and Inhibit Hyperactive Microglia In Vitro[J]. ACS Pharmacology & Translational Science, 2024. |