| Bioactivity | HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a pseudoexon containing a premature termination codon (stop-codon psiExon), leading to HTT mRNA degradation and reduction of HTT levels. HTT-D3 reduces p-glycoprotein (P-gp) efflux, and can be uesd for Huntington's disease research[1]. |
| Name | HTT-D3 |
| CAS | 2254502-89-9 |
| Formula | C23H25FN6 |
| Molar Mass | 404.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Anuradha Bhattacharyya, et al. Small molecule splicing modifiers with systemic HTT-lowering activity. Nat Commun. 2021 Dec 15;12(1):7299. |
HTT-D3
CAS: 2254502-89-9 F: C23H25FN6 W: 404.48
HTT-D3 is a potent and orally active huntingtin (HTT) splicing modulator. HTT-D3 acts by promoting the inclusion of a ps
Data collection：peptidedb@qq.com
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