| Bioactivity | HTRA1-IN-1 (Compound 17) is a selective inhibitor for serine protease high temperature requirement A serine peptidase 1 (HTRA1), with IC50 of 13 nM. HTRA1-IN-1 is potential for ameliorating HTRA1-related diseases, such as age-related macular degeneration (AMD), osteoarthritis, and rheumatoid arthritis[1]. |
| Formula | C31H43BClN3O5 |
| Molar Mass | 583.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Dennis DG, et al., Identification of highly potent and selective HTRA1 inhibitors. Bioorg Med Chem Lett. 2024 May 28;109:129814. |