| Bioactivity | HTR2A antagonist 1 (Compound 15f) is a HTR2A antagonist, with an IC50 of 42.79 nM. HTR2A antagonist 1 induces sub-G1 cell cycle arrest and apoptosis in colorectal cancer cells via the activation of p53/p21/caspase 3 signaling. HTR2A antagonist 1 has good liver microsomal stability. HTR2A antagonist 1 can be used for the research of colorectal cancer[1]. |
| Formula | C35H43Cl2F2N5O4 |
| Molar Mass | 706.65 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim M, et al. Synthesis and Biological Evaluation of Peripheral HTR2A Antagonists for Colorectal Cancer. J Med Chem. 2025 Jan 23;68(2):1716-1730. |
HTR2A antagonist 1
CAS: F: C35H43Cl2F2N5O4 W: 706.65
HTR2A antagonist 1 (Compound 15f) is a HTR2A antagonist, with an IC50 of 42.79 nM. HTR2A antagonist 1 induces sub-G1 cel
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