| Bioactivity | HSP90-IN-19 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-19 has effective Hsp90 inhibitory activity with an IC50 value of 0.27 μM. HSP90-IN-19 can be used for the research of viral infection, neurodegenerative disease, and inflammation[1]. |
| Target | IC50: 0.27 μM (Hsp90); ＞40 μM (MCF-7); ＞40 (SW480); ＞40 μM (A549); 16.95 μM (HL60); ＞40 μM (SMMC-7721) |
| Invitro | HSP90-IN-19 具有有效的 Hsp90 抑制活性，IC50 值为 0.27 μM[1]。HSP90-IN-19 (40, 8, 1.6, 0.32, 0.064 μM; 48 h) 对 MCF-7、SW480、A549、HL60 和 SMMC-7721 具有抗增殖活性，IC50 值分别为＞40 μM、＞40 μM、＞40 μM、16.95 μM 和 ＞40 μM[1]. |
| Name | HSP90-IN-19 |
| Formula | C29H38O7 |
| Molar Mass | 498.61 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Meng Li, et al. Design, synthesis and biological evaluation of a new class of Hsp90 inhibitors vibsanin C derivatives. Eur J Med Chem. 2022 Dec 15;244:114844. |