| Bioactivity | HSP90-IN-18 is an effective heat shock protein 90 (Hsp90) inhibitor. HSP90-IN-18 has effective Hsp90 inhibitory activity with an IC50 value of 0.39 μM. HSP90-IN-18 can be used for the research of viral infection, neurodegenerative disease, and inflammation[1]. |
| Target | IC50: 0.39 μM (Hsp90); 17.65 μM (MCF-7); 20.03 μM (SW480); ＞40 μM (A549); 3.69 μM (HL60); 11.92 μM (SMMC-7721) |
| Invitro | HSP90-IN-18 具有有效的 Hsp90 抑制活性，IC50 值为 0.39 μM[1]。HSP90-IN-18 (40, 8, 1.6, 0.32, 0.064 μM; 48 h) 对 MCF-7、SW480、A549、HL60 和 SMMC-7721 具有抗增殖活性，IC50 值分别为 17.65 μM、20.03 μM、＞40 μM、3.69 μM 和 11.92 μM[1]。HSP90-IN-18 (0, 1, 5, 10, 20 μM; 12-16 h) 通过线粒体介导的细胞凋亡途径促进 HL-60 细胞凋亡[1]。 Cell Proliferation Assay[1] Cell Line: |
| In Vivo | HSP90-IN-18（i.p.；100 mg/kg；持续 14 天）抑制 H22 荷瘤小鼠模型中的肿瘤生长，并显示出对小鼠的低急性毒性[1]。 Animal Model: |
| Name | HSP90-IN-18 |
| Formula | C25H33FO3 |
| Molar Mass | 400.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Meng Li, et al. Design, synthesis and biological evaluation of a new class of Hsp90 inhibitors vibsanin C derivatives. Eur J Med Chem. 2022 Dec 15;244:114844. |