| Bioactivity | HSDVHK-NH2 is an antagonist of the integrin αvβ3-vitronectin interaction, with an IC50 of 1.74 pg/mL (2.414 pM)[1][2]. | ||||||
| Invitro | HSDVHK significantly inhibited bFGF-induced cell migration compared to the PBS control group[1].The Arg-Gly-Asp (RGD)-binding site recognition by HSDVHK-NH2 (P11) is site specific because the HSDVHK-NH2 (P11) is inactive for the complex formation of a denatured form of integrin–vitronectin. HSDVHK-NH2 (P11) shows a strong antagonism against avb3-GRGDSP interaction with an IC50 value of 25.72 nM[2].HSDVHK-NH2 (P11) inhibits the HUVEC proliferation due to the induction of HUVEC cell death through caspases activations and its mechanism is related with increased p53 expression[3]. Cell Proliferation Assay[3] Cell Line: | ||||||
| Name | HSDVHK-NH2 | ||||||
| CAS | 848644-86-0 | ||||||
| Shortening | HSDVHK-NH2 | ||||||
| Formula | C30H48N12O9 | ||||||
| Molar Mass | 720.78 | ||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||
| Storage | Sealed storage, away from moisture and light
*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |