| Bioactivity | HS-291 is a HtpG inhibitor of Borrelia burgdorferi (Bb). HS-291 contains BX-2819 (high affinity for Bb HtpG), PEG linker, and Verteporfin (HY-B0146) (a photoactive toxin).HS-291 produces reactive oxygen species under light activation to oxidize HtpG and a discrete protein subset near chaperone proteins and can quickly and irreversibly inactivate Bb[1]. |
| Invitro | HS-291 (0.1-10 μM, 24 h) 在 nrIR (Ex: 693nm 5 J/cm2) 的激发下抑制 Bb 培养活性[1]。HS-291 (10 μM, 90 min) 在 Bb 培养中能够特异性靶向 Bb[1]。HS-291 (0-10 μM, 24 h) 在 nrIR (Ex: 693nm 5 J/cm2) 的激发下导致细胞的细胞壁起泡，类核凝结，细胞壁完整性丧失[1]。 0 --> HS-291 相关抗体: |
| Name | HS-291 |
| Formula | C156H194N18O36S2 |
| Molar Mass | 2961.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Carlson DL, et al. Targeting Borrelia burgdorferi HtpG with a berserker molecule, a strategy for anti-microbial development. Cell Chem Biol. 2023 Nov 1:S2451-9456(23)00340-9. |