| Bioactivity | HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly selectively inhibits the synthesis of PGD2, and acts as an anti-allergic agent, with a Kd of 0.8 μM and an IC50 of 6 μM. Shows no obvious effect on COX-1, COX-2, m-PGES, or L-PGDS[1]. | ||||||||||||
| Target | IC50: 6 μM (H-PGDS)Kd: 0.8 μM (H-PGDS) | ||||||||||||
| Invitro | HQL-79 is a competitive inhibitor against substrate PGH2 and a non-competitive one against GSH[1]. | ||||||||||||
| Name | HQL-79 | ||||||||||||
| CAS | 162641-16-9 | ||||||||||||
| Formula | C22H27N5O | ||||||||||||
| Molar Mass | 377.48 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Aritake K, et al. Structural and functional characterization of HQL-79, an orally selective inhibitor of human hematopoietic prostaglandin D synthase. J Biol Chem. 2006 Jun 2;281(22):15277-86. Epub 2006 Mar 17. |
HQL-79
CAS: 162641-16-9 F: C22H27N5O W: 377.48
HQL-79, a potent, selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor, highly se
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