HPK1-IN-52_product_DataBase

Bioactivity	HPK1-IN-52 is a potent and orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 10.4 nM. HPK1-IN-52 exhibits anti-tumor activities[1].
Invitro	HPK1-IN-52 (compound 24) 表现出相当的活性（IC50 为 10.4 nM）和细胞效力（pSLP76 EC50 为 41 nM 和 IL-2 EC50 为 108 nM）[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> HPK1-IN-52 相关抗体:
In Vivo	HPK1-IN-52（compound 24；30 mg/kg；口服；每日两次；持续两周）表现出中等程度的肿瘤生长抑制 (TGI)，为 42%[1]。HPK1-IN-52 在小鼠中的血浆清除率显著提高 (Clp = 46 mL/min/kg)，其口服暴露量显著增加 (AUC(0–24h) = 4139 h ng/mL)。此外，HPK1-IN-52 在大鼠中表现出较低的体内清除率 (Clp = 67 mL/min/kg) 和较高的口服暴露量 (AUC(0–24h) = 2013 h ng/mL)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model:
CAS	2994298-66-5
Formula	C31H30F2N6O2
Molar Mass	556.61
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Jingjing Peng, et al. Discovery of 1(2H)-phthalazinone and 1(2H)-isoquinolinone derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. European Journal of Medicinal Chemistry. Volume 279, 5 December 2024, 116877.

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