| Bioactivity | HPK1-IN-43 (compound 9f) is a HPK1 kinase inhibitor with the IC50 value of 0.32 nM. HPK1-IN-43 inhibits the phosphorylation of the downstream protein SLP-76 and enhances the secretion of interleukin-2 (IL-2) and interferon-γ (IFN-γ). HPK1-IN-43 can be used in cancer research[1]. |
| Invitro | HPK1-IN-43 (compound 9f) (0-100 nM, 1-18 h) 抑制 Jurkat 和原代外周血单核细胞 (PBMC) 中 SLP76 的磷酸化，IC50 值分别为 147.9 nM 和 131.8 nM。HPK1-IN-43 可促进 PBMC 中 IL-2 和 IFN-γ 的产生[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> HPK1-IN-43 相关抗体: |
| Formula | C26H25F3N6O2 |
| Molar Mass | 510.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Qiu X, et al. Discovery of 5-aminopyrido[2,3-d]pyrimidin-7(8H)-one derivatives as new hematopoietic progenitor kinase 1 (HPK1) inhibitors. Eur J Med Chem. 2024 Apr 5;269:116310. |