| Bioactivity | HPK1-IN-35 is a potent and selective HPK1 inhibitor with an IC50 value of 3.5 nM. HPK1-IN-35 decreases the expression of p-SLP76 and promotes IL-2 secretion[1]. |
| Invitro | HPK1-IN-35 (compound 31) (0.1, 0.3, 1, 3 µM; 1 h) 以剂量依赖性方式降低抗 CD3 抗体 (1 µg/mL) 刺激的 p-SLP76 的表达 [1].HPK1-IN-35 (0-10 µM; 24 h) 以剂量依赖性方式促进 Jurkat 细胞分泌 IL-2，EC50 值为 1.19 μM[1]。 Western Blot Analysis [1] Cell Line: |
| Name | HPK1-IN-35 |
| Formula | C30H32N8O3S |
| Molar Mass | 584.69 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Feifei Wu, et al. Discovery of 7H-Pyrrolo[2,3-d]pyrimidine Derivatives as potent hematopoietic progenitor kinase 1 (HPK1) inhibitors. European Journal of Medicinal Chemistry. 2023, 254: 115355. |