| Bioactivity | HPK1-IN-31 (compound 5i) is an orally active hematopoietic progenitor kinase 1 (HPK1) inhibitor with an IC50 value of 0.8 nM. HPK1-IN-31 has anti-tumour activity and has great potential for immunotherapy[1]. |
| In Vivo | HPK1-IN-31(compound 5i) (p.o., 30 或 100 mpk，每天两次，14天) 在 CT26 肿瘤雌性 BALB/c 小鼠模型和 MC38 肿瘤雌性 C57BL/6 小鼠模型中，可以抑制肿瘤的生长，并且与抗 PD-1 单药联用时效果更明显[1]。 |
| Name | HPK1-IN-31 |
| Formula | C30H33N7O3 |
| Molar Mass | 539.63 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ming-Shu Wang, et al. Discovery of Macrocycle-Based HPK1 Inhibitors for T-Cell-Based Immunotherapy. J Med Chem. 2023 Jan 12;66(1):611-626. |