| Bioactivity | HO-3867 is a selective and potent STAT3 inhibitor and shows good antitumor activity. | ||||||||||||
| Invitro | HO-3867 exhibit minimal toxicity toward noncancerous cells and tissues but induce apoptosis in ovarian cancer cells. HO-3867 inhibit cell migration/invasion and survival by inhibiting STAT3 phosphorylation[1]. BRCA-mutated ovarian cancer cells treated with HO-3867 exhibited a significant degree of apoptosis with elevated levels of cleaved caspase-3, caspase-7 and PARP[2]. HO-3867 shows good antitumor activity at the concentration of 2 μmol/L in PANC-1 and BXPC-3 cells. Importantly, it is also found that HO-3867 treatment significantly induced reactive oxygen species (ROS) production in human pancreatic cancer cell lines, inducing PANC-1 and BXPC-3 cells[3]. | ||||||||||||
| Name | HO-3867 | ||||||||||||
| CAS | 1172133-28-6 | ||||||||||||
| Formula | C28H30F2N2O2 | ||||||||||||
| Molar Mass | 464.55 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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