| Bioactivity | HNMPA is a membrane impermeable insulin receptor tyrosine kinase inhibitor. HNMPA inhibits serine and tyrosine autophosphorylation by the human insulin receptor. HNMPA has no effect on protein kinase C or cyclic AMP-dependent protein kinase activities[1][2] |
| Invitro | HNMPA inhibits the phosphorylation of a synthetic peptide substrate composed of insulin receptor residues 1290-1319 on serines-1305/1306 by partially purified insulin receptors[1].HNMPA blocks GABA-dependent insulin inhibition, and reduces neuronal firing after GABA application[2]. |
| Name | HNMPA |
| CAS | 132541-52-7 |
| Formula | C11H11O4P |
| Molar Mass | 238.18 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. K Baltensperger, et al. Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. Proc Natl Acad Sci U S A. 1992 Sep 1;89(17):7885-9. [2]. Peter Kovacs, et al. In vivo electrophysiological effects of insulin in the rat brain. Neuropeptides. 2009 Aug;43(4):283-93. |