| Bioactivity | HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left ventricular myocytes, respectively[1][2]. | ||||||||||||
| Target | IC50: 10.5 nM (IKs in canine left ventricular myocytes), 34 nM (IKs in guinea pig left ventricular myocytes) | ||||||||||||
| Invitro | HMR 1556 inhibits Ito, ICa,L and IKr with IC50s of 33.9 μM, 27.5 μM, 12.6 μM in canine left ventricular myocytes, respectively[1]. | ||||||||||||
| Name | HMR 1556 | ||||||||||||
| CAS | 223749-46-0 | ||||||||||||
| Formula | C17H24F3NO5S | ||||||||||||
| Molar Mass | 411.44 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Thomas GP, et al. HMR 1556, a potent and selective blocker of slowly activating delayed rectifier potassium current. J Cardiovasc Pharmacol. 2003 Jan;41(1):140-7. [2]. Gerlach U,et al. Synthesis and activity of novel and selective I(Ks)-channel blockers. J Med Chem. 2001 Nov 8;44(23):3831-7. |
HMR 1556
CAS: 223749-46-0 F: C17H24F3NO5S W: 411.44
HMR 1556, a chromanol derivative, is a potent IKs blocker with IC50s of 10.5 nM and 34 nM in canine and guinea pig left
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.