| Bioactivity | HLY78, a Lycorine (HY-N0288) derivative, is a potent activator of the Wnt/β-catenin signaling pathway. HLY78 targets the DIX domain of Axin and promotes the Axin-LRP6 (lipoprotein receptor-related protein 6) association, thus promoting LRP6 phosphorylation and Wnt signal transduction. HLY78 can be used for subarachnoid hemorrhage (SAH) research[1][2][3]. | ||||||||||||
| Invitro | HLY78 inhibits apoptosis in tumor cells and embryonic cells caused by carbon ion radiation through activation of the Wnt/β-catenin pathway[2].HLY78 (20 μM, 0-48 h) significantly increases the colony formation ability by 2.78-fold and 2.88-fold for HGC-27 and AGS cells compared with the controls[3].HLY78 (20 μM, 0-48 h) elevates the migration ability of HGC-27 and AGS cells[3].HLY78 significantly increases TNKS expression, which is ameliorated by Dihydroartemisinin (HY-N0176)[3]. | ||||||||||||
| Name | HLY78 | ||||||||||||
| CAS | 854847-61-3 | ||||||||||||
| Formula | C17H17NO2 | ||||||||||||
| Molar Mass | 267.32 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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