| Bioactivity | HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with Kd of 170 nM for Shh. HL2-m5 inhibits activation of Hedgehog signaling pathway and transcription of Gli-controlled gene with an IC50 of 230 nM[1]. |
| CAS | 2130846-15-8 |
| Sequence | Ac-Thr-Leu-Ser-Trp-cyclo[{O2beY}-Glu-Ala-Met-Asp-Met-Cys]-Thr-Asp-NH2 |
| Shortening | Ac-TLSW-cyclo[{O2beY}EAMDMC]-TD-NH2 |
| Formula | C70H101N15O24S3 |
| Molar Mass | 1632.83 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Owens AE, et al., Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction. J Am Chem Soc. 2017 Sep 13;139(36):12559-12568. |
HL2-m5
CAS: 2130846-15-8 F: C70H101N15O24S3 W: 1632.83
HL2-m5 is the inhibitor for the interaction between sonic hedgehog/patched (Shh/PTCH1) with Kd of 170 nM for Shh. HL2-m5
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