HJC0416_product_DataBase

Bioactivity	HJC0416 is a potent and orally active STAT3 inhibitor. HJC0416 shows antiprolifeative activity and induces apoptosis. HJC0416 decreases the expression of p-STAT3 (Tyr-705), Cyclin D1 and increases the expression of cleaved caspase-3 protein. HJC0416 shows anti-tumor activity[1].
Invitro	HJC0416 (0-10 µM; 48 h) 在 MDA-MB-231 细胞中显示抗增殖活性并诱导细胞凋亡[1]。HJC0416 (0-10 µM; 12 h) 降低 p-STAT3 (Tyr-705)、Cyclin D1 的表达并增加cleaved caspase-3 蛋白的表达[1]。 Cell Proliferation Assay[1] Cell Line:
In Vivo	HJC0416 (腹腔注射 10 mg/kg；口服 100 mg/kg；每日一次，持续 7 天) 在小鼠中减少肿瘤生长，体重没有明显减轻[1]。 Animal Model:
Name	HJC0416
CAS	1617518-22-5
Formula	C18H17ClN2O4S
Molar Mass	392.86
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Chen H, et al. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur J Med Chem. 2014 Jul 23;82:195-203.

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