HIV-1 inhibitor-66_product_DataBase

Bioactivity	HIV-1 inhibitor-66 is an orally active non-nucleoside reverse transcription inhibitor (NNRTI). HIV-1 inhibitor-66 shows inhibitory activity against wild-type HIV-1 reverse transcriptase with an IC50 of 40 nM[1].
Invitro	HIV-1 inhibitor-66 (compound 10n) 抑制野生型（WT）HIV-1（IIIB）和NNRTIs耐药株，针对 HIV-1 IIIB、L100I、K103N、Y181C、Y188L、E138 K、F227L/V106A 和 RES056 (K103N/Y181C) 的 EC50 值分别为 0.009 μM、0.011 μM、0.013 μM、0.018 μM、0.703 μM、0.013 μM、17.7 μM 和 0.059 μM[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> HIV-1 inhibitor-66 相关抗体:
In Vivo	HIV-1 inhibitor-66 (compound 10n) 在大鼠中表现出优异的药代动力学特征 (T1/2=5.09 h，F=108.96%)。HIV-1 inhibitor-66 经验证在体内无急性或亚急性毒性 (LD50>2000 mg/kg)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Formula	C22H15BrClF3N4O3
Molar Mass	555.73
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Yanying Sun, et al. Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs. J Med Chem. 2024 Apr 25;67(8):6570-6584.

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