HIV-1 inhibitor-52_product_DataBase

Bioactivity	HIV-1 inhibitor-52 is a potent broad-spectrum HIV-1 activity inhibitor with EC50s of 1.6 nM-6.4 nM for WT HIV-1, HIV-1 V370A, HIV-1 ΔV370, HIV-1 V362I/V370A, HIV-1 T332S/V362I/prR41G, HIV-1 A326T/V362I/V370A, HIV-1 R361K/V362I/L363M[1].
In Vivo	HIV-1 inhibitor-52 (化合物 26; 1 mg/kg; 静脉给药) 在大鼠的 T1/2 为 4.2 小时，CL 为 3.5 mL/min·kg，Vss 为 0.8 L/kg[1]。 HIV-1 inhibitor-52 (5 mg/kg; 灌胃) 对大鼠的 Cmax 为 0.83 μM，AUC 为 8.11 μM·h[1]。 Animal Model:
Name	HIV-1 inhibitor-52
CAS	1818868-23-3
Formula	C46H72FNO5S
Molar Mass	770.13
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Richard A Hartz, et al. Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity. J Med Chem. 2022 Dec 8;65(23):15935-15966.

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