HIV-1 inhibitor-45

CAS: 2677762-43-3 F: C23H24N4O8S W: 516.52

HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-

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Bioactivity	HIV-1 inhibitor-45 (compound IA-6) is a potent HIV-1 RNase H inhibitor with an IC50 value of 0.067 μM. HIV-1 inhibitor-45 shows an antiviral activity[1].
Target	IC50: 0.067 μM (HIV-1 RNase H)
Invitro	HIV-1 inhibitor-45 (compound IA-6) (5 d) has antiviral activity and low toxicity with CC50 value of 24.7 μM in MT-4 cells[1].HIV-1 inhibitor-45 (compound IA-6) (Caco-2 cells) contributes to the poormembrane permeability by polyphenolic skeleton[1].
Name	HIV-1 inhibitor-45
CAS	2677762-43-3
Formula	C23H24N4O8S
Molar Mass	516.52
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhang L, et, al. Design, synthesis, and biological evaluation of novel double-winged galloyl derivatives as HIV-1 RNase H inhibitors. Eur J Med Chem. 2022 Jun 26;240:114563.