| Bioactivity | HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agonist 2 is non-cytotoxic against 786-O-HRE-Luc cells. HIF-2α agonist 2 can be used for oxygen metabolism research[1]. | |||||||||
| Invitro | HIF-2α agonist 2 (0.001-100 μM；24 h) 剂量依赖性地激活 HIF-2，在 20 μM 剂量下 EC50 值为 1.68 μM[1]。HIF-2α agonist 2 (0.003-20 μM；24 h) 对 786-O-Luc 细胞无细胞毒性[1]。 Cell Viability Assay[1] Cell Line: | |||||||||
| Name | HIF-2α agonist 2 | |||||||||
| CAS | 2750141-15-0 | |||||||||
| Formula | C13H8Br2N2O2S | |||||||||
| Molar Mass | 416.09 | |||||||||
| Appearance | Solid | |||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | |||||||||
| Storage |
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| Reference | [1]. Yu Y, et al. Insight into the binding mode of HIF-2 agonists through molecular dynamic simulations and biological validation. Eur J Med Chem. 2021 Feb 5;211:112999. |
HIF-2α agonist 2
CAS: 2750141-15-0 F: C13H8Br2N2O2S W: 416.09
HIF-2α agonist 2 (compound 10) is a HIF-2α agonist with an EC50 value of 1.68 μM at the dose of 20 μM. HIF-2α agoni
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