| Bioactivity | HIF-1 inhibitor-5 (Compound 16e) is a potent HIF-1 inhibitor with an IC50 of 2.38 μM. HIF-1 inhibitor-5 possesses anti-angiogenic potential[1]. |
| Target | IC50: 2.38 μM (HIF-1) |
| Invitro | HIF-1 inhibitor-5 (Compound 16e; 0-4 μM; 24 h) 抑制 A549 细胞迁移和侵袭[1]。HIF-1 inhibitor-5 (0-8 μM; 12 h) 阻断 VEGF 诱导的血管形成[1]。 Cell Cytotoxicity Assay[1] Cell Line: |
| In Vivo | HIF-1 inhibitor-5 (Compound 16e; 1.25-20 μM; s.c.; once) 抑制 VEGF 诱导的小鼠血管生成[1]。 Animal Model: |
| Name | HIF-1 inhibitor-5 |
| Formula | C28H35NO5 |
| Molar Mass | 465.58 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Xu H, et al. Design, synthesis and evaluation of the novel chalcone derivatives with 2,2-dimethylbenzopyran as HIF-1 inhibitors that possess anti-angiogenic potential. Eur J Med Chem. 2023 Mar 15;250:115171. |