| Bioactivity | HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex between TRIM21 and NUP98, induces degradation of NUP155 and nuclear pore complex proteins, thereby causing the cell death. HGC652 inhibits the proliferation of multi cancer cells, according to the expression level of TRIM21[1]. |
| CAS | 3055558-98-7 |
| Formula | C23H28FNO3S2 |
| Molar Mass | 449.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Li X, et al. Chemically Induced Nuclear Pore Complex Protein Degradation via E3 Ligase TRIM21[J]. bioRxiv, 2024: 2024.12. 03.626577. |
HGC652
CAS: 3055558-98-7 F: C23H28FNO3S2 W: 449.60
HGC652 is the molecular glue, that targets E3 ubiquitin ligase TRIM21, promotes the formation of a ternary complex betwe
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