| Bioactivity | HG-7-85-01-NH2 is the ligand of SNIPER(ABL)-033. SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 derivative (IAP ligand) with a linker, induces the reduction of BCR-ABL protein with a DC50 value of 0.3 μM[1]. | ||||||||||||
| Name | HG-7-85-01-NH2 | ||||||||||||
| CAS | 1258391-29-5 | ||||||||||||
| Formula | C27H27F3N6OS | ||||||||||||
| Molar Mass | 540.60 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Shibata N, et al. Development of protein degradation inducers of oncogenic BCR-ABL protein by conjugation of ABL kinase inhibitors and IAP ligands. Cancer Sci. 2017 Aug;108(8):1657-1666. |
HG-7-85-01-NH2
CAS: 1258391-29-5 F: C27H27F3N6OS W: 540.60
HG-7-85-01-NH2 is the ligand of SNIPER(ABL)-033. SNIPER(ABL)-033, conjugating HG-7-85-01 (ABL inhibitor) to LCL161 deriv
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