| Bioactivity | HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 µM. HEC72702 dose-dependently reduced HBV DNA in both the plasma and livers[1]. |
| Target | EC50: 0.039 µM (hepatitis B virus capsid) |
| In Vivo | HEC72702 (50、100 mg/kg；口服；每日一次，连续 7 天) 剂量依赖性地减少血浆和肝脏中的 HBV DNA 拷贝数[1]。 Animal Model: |
| Name | HEC72702 |
| CAS | 1793063-59-8 |
| Formula | C24H26BrFN4O5S |
| Molar Mass | 581.45 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ren Q, et al. 3-((R)-4-(((R)-6-(2-Bromo-4-fluorophenyl)-5-(ethoxycarbonyl)-2-(thiazol-2-yl)-3,6-dihydropyrimidin-4-yl)methyl)morpholin-2-yl)propanoic Acid (HEC72702), a Novel Hepatitis B Virus Capsid Inhibitor Based on Clinical Candidate GLS4. J Med Chem. 2018 Feb 8;61(3):1355-1374. |
HEC72702
CAS: 1793063-59-8 F: C24H26BrFN4O5S W: 581.45
HEC72702 is a potent and orally active hepatitis B virus capsid inhibitor with an EC50 values of 0.039 µM. HEC72702 dos
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