| Bioactivity | HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-related protein 2 (HDGFRP2) and its homologous protein PSIP1, hinder the development and progression of diffuse intrinsic pontine glioma (DIPG). HDGFRP2/PSIP1-IN-1 binds to HDGFRP2 with a Kd value of 7 μM and a ligand efficiency of 0.47; it binds to the PSIP1 PWWP domain with a Kd value of 27 μM; meanwhile, it has a Kd value of 14 μM for HDGFRP3, indicating its effectiveness as an inhibitor of the HDGFRP2 PWWP subfamily[1]. | ||||||||||||
| Target | HDGFRP2/PSIP1-IN-1 与 HDGFRP2 结合的 Kd 值为 7 μM; 与 PSIP1 PWWP 结构域结合的 Kd 值为 27 μM; 对 HDGFRP3 的 Kd 值为 14 μM。 | ||||||||||||
| CAS | 166196-54-9 | ||||||||||||
| Formula | C8H6BrN3 | ||||||||||||
| Molar Mass | 224.06 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Xiaoli Wei, et al. Fragment-based discovery of small molecule inhibitors of the HDGFRP2 PWWP domain. FEBS Lett. 2024 Jul 19.1873-3468.14981. |
HDGFRP2/PSIP1-IN-1
CAS: 166196-54-9 F: C8H6BrN3 W: 224.06
HDGFRP2/PSIP1-IN-1 (compound BPP) is a dual inhibitor targeting the PWWP domain of hepatocarcinogenic growth factor-rela
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