| Bioactivity | HDACs/mTOR Inhibitor 1 is a dual HDACs and mTOR inhibitor, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM for HDAC1, HDAC6, mTOR, respectively. HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induces tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 can be used in the research of hematologic malignancies[1][2]. | ||||||||||||
| Invitro | HDACs/mTOR Inhibitor 1 (Compound 12l) 抑制白血病细胞增殖，对 MV4-11, OCI-AML2, OCI-AML3IC 的50s 分别为 4.05, 9.01, 9.98 μM[1]。HDACs/mTOR Inhibitor 1 (0-10 μM, 6 h or 24 h) 在 MV4-11 细胞中下调 p-ERK 水平，上调 Ac-H3 水平[1]。HDACs/mTOR Inhibitor 1 (10 to 1000 nM, 48 h) 减少 S 期 MV4-11 细胞细胞并增加 G0/G1 期细胞的百分比[1]。 Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | HDACs/mTOR Inhibitor 1 | ||||||||||||
| CAS | 2271413-06-8 | ||||||||||||
| Formula | C28H38N8O5 | ||||||||||||
| Molar Mass | 566.65 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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HDACs/mTOR Inhibitor 1
CAS: 2271413-06-8 F: C28H38N8O5 W: 566.65
HDACs/mTOR Inhibitor 1 is a dual HDACs and mTOR inhibitor, with IC50s of 0.19 nM, 1.8 nM, 1.2 nM for HDAC1, HDAC6, mTOR,
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This product is for research use only, not for human use. We do not sell to patients.