| Bioactivity | HDAC8-IN-4 is a selective inhibitor of HDAC8. HDAC8-IN-4 inhibits HDAC8 and HDAC3 with IC50s of 0.15 and 12 μM[1]. |
| Invitro | HDAC8-IN-4 (化合物 9) (1-100 μM，5-6 天) 抑制 HeLa 细胞中的 HDAC8 蛋白水平[1]。HDAC8-IN-4 (约 0-50 μM，72 小时) 抑制 T 细胞淋巴瘤细胞 (Jurkat、HH、MT4、HUT78 细胞) 的生长[1]。 Cell Proliferation Assay[1] Cell Line: |
| Name | HDAC8-IN-4 |
| CAS | 1600528-05-9 |
| Formula | C17H14N2O2S2 |
| Molar Mass | 342.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Suzuki T, et al. Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors. ChemMedChem. 2014 Mar;9(3):657-64. |