| Bioactivity | HDAC6-IN-47 (Compound S-29b) is inhibitor for HDAC, which exhibits high affinities to HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, HDAC10 with Ki of 60, 56, 162, 0.44, 362 and 849 nM, respectively. HDAC6-IN-47 causes tubulin hyperacetylation in MV4-11, inhibits the proliferation of MV4-11 with an EC50 of 0.50 µM. HDAC6-IN-47 can be used in research of leukemia[1]. |
| Formula | C29H33N5O6 |
| Molar Mass | 547.60 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Scheuerer S, et al. Biological and structural investigation of tetrahydro-β-carboline-based selective HDAC6 inhibitors with improved stability[J]. European Journal of Medicinal Chemistry, 2024: 116676. |