| Bioactivity | HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247 induces a selective increase of NF-κB acetylation in HCT116 cells. HDAC3-IN-T247 shows anticancer and antiviral activity. HDAC3-IN-T247 inhibits growth of cancer cells, and activates HIV gene expression in latent HIV-infected cells[1]. | ||||||||||||
| Name | HDAC3-IN-T247 | ||||||||||||
| CAS | 1451042-18-4 | ||||||||||||
| Formula | C21H19N5OS | ||||||||||||
| Molar Mass | 389.47 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Suzuki T, et al. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 2013 Jul 16;8(7):e68669. |
HDAC3-IN-T247
CAS: 1451042-18-4 F: C21H19N5OS W: 389.47
HDAC3-IN-T247 is a potent and selective HDAC3 (histone deacetylase 3) inhibitor, with an IC50 of 0.24 µM. HDAC3-IN-T247
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