| Bioactivity | HDAC10-IN-2 hydrochloride (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC10-IN-2 hydrochloride modulates autophagy in aggressive FLT3-ITD positive acute myeloid leukemia cells[1]. |
| Target | IC50: 20 ± 2 nM (drHDAC10), 470 ± 70 nM (hHDAC8), 3700 ± 450 nM (hHDAC6) |
| Name | HDAC10-IN-2 hydrochloride |
| Formula | C19H23ClN2O2 |
| Molar Mass | 346.85 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zeyen P, et al. Identification of histone deacetylase 10 (HDAC10) inhibitors that modulate autophagy in transformed cells. Eur J Med Chem. 2022 Apr 15;234:114272. |
HDAC10-IN-2 hydrochloride
CAS: F: C19H23ClN2O2 W: 346.85
HDAC10-IN-2 hydrochloride (compound 10c) is a potent and highly selective HDAC10 inhibitor, with an IC50 of 20 nM. HDAC1
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