HDAC-IN-67_product_DataBase

Bioactivity	HDAC-IN-67 (compound 27f) is an HDAC inhibitor against HDAC1 and HDAC6, with IC50 values of 22 nM and 8 nM, respectively. HDAC-IN-67 inhibits cell proliferation and induces cell apoptosis. HDAC-IN-67 exhibits antitumor activity[1].
Invitro	HDAC-IN-67 在肿瘤细胞 K562，MV4-11，HEL，SU-DHL-2 和 WSU-DLCL-2 中表现出抗增殖活性，IC50 值分别为 4.42 μM，0.79 μM，2.43 μM，1.05 μM 和 1.43 μM[1]。HDAC-IN-67 诱导 WSU-DLCL-2 细胞凋亡 (10 μM：91.57%；5 μM：77.05%)[1]。 0 --> HDAC-IN-67 相关抗体: Cell Proliferation Assay[1] Cell Line:
In Vivo	HDAC-IN-67 (静脉注射，5 mg/kg) 在 ICR 小鼠中的清除率是 65.1 ml/(h·kg)，清除半衰期是 0.361 小时[1]。HDAC-IN-67 (口服，10 mg/kg) 的口服生物利用度低（F=3.15%）[1]。HDAC-IN-67 (腹腔注射，50 mg/kg，共 21 天) 在体内具有中等的抗肿瘤效力，TGI 为 31.5%[1]。 Animal Model:
Name	HDAC-IN-67
CAS	2821923-75-3
Formula	C30H47N5O3
Molar Mass	525.73
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Gao Y,et al., Design, synthesis and biological evaluation of novel histone deacetylase (HDAC) inhibitors derived from β-elemene scaffold. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2195991.

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